The affinity of the tissues for water, or, as Fischer explains it, the affinity of the tissue colloids for water, seems too little related to the requirements of ocular function to furnish the needed regulation of tension. The lymph spaces and blood-channels of the eye are large, as compared with the mass of its tissue colloids. In these spaces and channels must be sought a means for rapid response to the need for regulation of intra-ocular tension. Fischer has shown, that when the enucleated eyeball is placed in a weak solution of hydrochloric acid, the swelling of the tissue colloids is sufficient in a few hours, to burst the sclero-corneal coat. But this is an eye in which all nutritional changes have ceased. He brings together many facts to support the view that in the living tissues impaired circulation, and especially diminished oxidation, are the chief causes of increased affinity of the colloids for water. Such affinity increased by the impairment of the intra-ocular circulation, may well constitute a factor making for malignancy in glaucoma. But it can hardly explain the original departure from a normal pressure balance. We must assume that intra-ocular pressure is kept down to the normal limit, by the prompt response of a regulative mechanism, which diminishes the flow of fluid into the eye, or permits its more rapid escape, whenever fluid tends to accumulate in the eye and increase its tension. Little has been done to show that increase of fluid entering into the eye is the cause of glaucoma. A normal, or even a low arterial blood pressure is sufficiently above the normal intra-ocular pressure to furnish a source of increased fluid in the eye. Increased arterial pressure has been found in a large proportion of cases of glaucoma; and may be necessary to the production of the highest intra-ocular tension. A sudden relaxation of the arterial walls, that would permit the arterial blood pressure to make itself felt in the eye, might cause an important rise of intra-ocular tension and may be a factor in the etiology of acute attacks. It affords a possible mechanism through which may be produced the recognized glaucomatous effects of certain nerve disturbances. But such attacks are not commonly associated with noticeable flushing of the head and face generally; and paralysis of the cervical sympathetic is known to lower the intra-ocular tension. Capillary blood pressure must lie between the arterial blood pressure and the venous blood pressure. It must be closely associated with the nutritional processes like secretion or inflammation; beyond this we know little about it. The association of increased blood pressure with glaucoma seems to be generally an indirect one through vascular lesions and disturbances of nutrition. _Obstructed Outflow_