When we consider the almost universal use of tobacco, especially in the form of smoking, among our male population, it is not to be wondered at that this powerful poison has come to be regarded as an innocent and almost necessary vegetable production, not to be used as food exactly, but greatly allied to it as an article of daily consumption. Few stop to reason about its properties or effects; they remember, perhaps, how sick they were made by the first chew or smoke, but this having long passed, believe that as their systems have become accustomed, _apparently_, to the poison, it cannot be doing them any real injury. When we reflect that tobacco contains from one to nearly seven per cent, of _nicotine_--one of the most powerful vegetable poisons known--a few drops of which are sufficient to destroy life, it is not difficult to perceive that this faith in the _innocence_ begotten of use must be fallacious. We have met with instances where the poisonous effects of tobacco were manifest after every smoke, even where the attempt to accustom the system to its use had been persevered in for many years; and yet the men never realized what was the matter with them, until they had, under medical advice, ceased to use the drug. Before the discovery of anæsthetics, tobacco was used as a remedy to produce relaxation in cases of strangulated hernia; and although very cautiously administered in the form of tea, or smoke per rectum, proved fatal in many instances. As little as twelve grains in six ounces of water having thus acted; and from half a drachm to two drachms in a number of instances. When men chew as high as a pound and a quarter of strong navy tobacco a week, or three packages of fine-cut in a day, it must certainly tell upon them sooner or later; or even in much less quantity. If men used tobacco in moderation, there would be much less objection to it, if it was not so intimately ASSOCIATED WITH THE HABIT OF DRINKING. This is recognized by the trade, in the fact that we see many tobacco stores as the entrance to drinking saloons. Ninety-three per cent. of the men who have been admitted to the Franklin Reformatory Home used tobacco, and eighty per cent. of them chewed it. There may be possibly as high as ninety-three per cent. of male adults who smoke, but eighty per cent. of chewers is undoubtedly a large proportion as compared with those in the same ranks of society who do not drink.