I have endeavored, in the first part of this discourse, to give you a conception of the direction towards which modern physiology is tending; and I ask you, what is the difference between the conception of life as the product of a certain disposition of material molecules, and the old notion of an Archæus governing and directing blind matter within each living body, except this—that here, as elsewhere, matter and law have devoured spirit and spontaneity? And as surely as every future grows out of past and present, so will the physiology of the future gradually extend the realm of matter and law until it is coëxtensive with knowledge, with feeling, and with action. The consciousness of this great truth weighs like a nightmare, I believe, upon many of the best minds of these days. They watch what they conceive to be the progress of materialism, in such fear and powerless anger as a savage feels, when, during an eclipse, the great shadow creeps over the face of the sun. The advancing tide of matter threatens to drown their souls; the tightening grasp of law impedes their freedom; they are alarmed lest man’s moral nature be debased by the increase of his wisdom. If the “New Philosophy” be worthy of the reprobation with which it is visited, I confess their fears seem to me to be well founded. While, on the contrary, could David Hume be consulted, I think he would smile at their perplexities, and chide them for doing even as the heathen, and falling down in terror before the hideous idols their own hands have raised. For, after all, what do we know of this terrible “matter,” except as a name for the unknown and hypothetical cause of states of our own consciousness? And what do we know of that “spirit” over whose threatened extinction by matter a great lamentation is arising, like that which was heard at the death of Pan, except that it is also a name for an unknown and hypothetical cause, or condition, of states of consciousness? In other words, matter and spirit are but names for the imaginary substrata of groups of natural phenomena. And what is the dire necessity and “iron” law under which men groan? Truly, most gratuitously invented bugbears. I suppose if there be an “iron” law, it is that of gravitation; and if there be a physical necessity, it is that a stone, unsupported, must fall to the ground. But what is all we really know and can know about the latter phenomenon? Simply, that, in all human experience, stones have fallen to the ground under these conditions; that we have not the smallest reason for believing that any stone so circumstanced will not fall to the ground, and that we have, on the contrary, every reason to believe that it will so fall. It is very convenient to indicate that all the conditions of belief have been fulfilled in this case, by calling the statement that unsupported stones will fall to the ground, “a law of nature.” But when, as commonly happens, we change will into must, we introduce an idea of necessity