The symptoms produced are general, rather than local. As summarized by Kobert (1901) from a study of twenty-two cases treated in 1888, in the Kherson (Russia) Government Hospital and Berislaw (Kherson) District Hospital the typical case, aside from complications, exhibits the following symptoms. The victim suddenly feels the bite, like the sting of a bee. Swelling of the barely reddened spot seldom follows. The shooting pains, which quickly set in, are not manifested at the point of injury but localized at the joints of the lower limb and in the region of the hip. The severity of the pain forces the victim to the hospital, in spite of the fact that they otherwise have a great abhorrence of it. The patient is unable to reach the hospital afoot, or, at least, not without help, for there is usually inability to walk. The patient, even if he has ridden, reaches the hospital covered with cold sweat and continues to perspire for a considerable period. His expression indicates great suffering. The respiration may be somewhat dyspnœic, and a feeling of oppression in the region of the heart is common. There is great aversion to solid food, but increasing thirst for milk and tea. Retention of urine, and constipation occur. Cathartics and, at night, strong narcotics are desired. Warm baths give great relief. After three days, there is marked improvement and usually the patient is dismissed after the fifth. This summary of symptoms agrees well with other trustworthy records. It would seem, then, that Riley and Howard (1889), who discussed a number of accounts in the entomological literature, were fully justified in their statement that "It must be admitted that certain spiders of the genus _Latrodectus_ have the power to inflict poisonous bites, which may (probably exceptionally and depending upon exceptional conditions) bring about the death of a human being." And yet, until recently the evidence bearing on the question has been most conflicting. The eminent arachnologist, Lucas, (1843) states that he himself, had been repeatedly bitten by the Malmigniatte without any bad effects. Dr. Marx, in 1890, gave before the Entomological Society of Washington, an account of a series of experiments to determine whether the bite of _Latrodectus mactans_ is poisonous or not. He described the poison glands as remarkably small[A] and stated that he had introduced the poison in various ways into guinea-pigs and rabbits without obtaining any satisfactory results. Obviously, carefully conducted experiments with the supposed venom were needed and fortunately they have been carried out in the greatest detail by Kobert (1901).