The theory of Mercurialis was not wholly lost sight of, for in the medical literature of the eighteenth century there are scattered references to flies as carriers of disease. Such a view seems even to have been more or less popularly accepted, in some cases. Gudger (1910), has pointed out that, as far back as 1769, Edward Bancroft, in "An Essay on the Natural History of Guiana in South America," wrote concerning the contagious skin-disease known as "Yaws": "It is usually believed that this disorder is communicated by the flies who have been feasting on a diseased object, to those persons who have sores, or scratches, which are uncovered; and from many observations, I think this is not improbable, as none ever receive this disorder whose skins are whole." Approaching more closely the present epoch, we find that in 1848, Dr. Josiah Nott, of Mobile, Alabama, published a remarkable article on the cause of yellow fever, in which he presented "reasons for supposing its specific cause to exist in some form of insect life." As a matter of fact, the bearing of Nott's work on present day ideas of the insect transmission of disease has been very curiously overrated. The common interpretation of his theory has been deduced from a few isolated sentences, but his argument appears quite differently when the entire article is studied. It must be remembered that he wrote at a period before the epoch-making discoveries of Pasteur and before the recognition of micro-organisms as factors in the cause of disease. His article is a masterly refutation of the theory of "malarial" origin of "all the fevers of hot climates," but he uses the term "insect" as applicable to the lower forms of life, and specific references to "mosquitoes," "aphids," "cotton-worms," and others, are merely in the way of similes. But, while Nott's ideas regarding the relation of insects to yellow fever were vague and indefinite, it was almost contemporaneously that the French physician, Louis Daniel Beauperthuy argued in the most explicit possible manner, that yellow fever and various others are transmitted by mosquitoes. In the light of the data which were available when he wrote, in 1853, it is not surprising that he erred by thinking that the source of the virus was decomposing matter which the mosquito took up and accidentally inoculated into man. Beauperthuy not only discussed the rôle of mosquitoes in the transmission of disease, but he taught, less clearly, that house-flies scatter pathogenic organisms. It seems that Boyce (1909) who quotes extensively from this pioneer work, does not go too far when he says "It is Dr. Beauperthuy whom we must regard as the father of the doctrine of insect-borne disease."