[Footnote 24: Perkin was the first of Lady Catherine Gordon's four husbands; her second was James Strangways, gentleman-usher to Henry VIII., her third Sir Matthew Cradock (d. 1531), and her fourth Christopher Ashton, also gentleman-usher; she died in 1537 and was buried in Fyfield Church (_L. and P._, ii., 3512).] [Footnote 25: See the present writer in _Dict. Nat. Biog._, lxiii., 172.] [Footnote 26: _Sp. Cal._, i., No. 249; see below, p. 179.] But all his statecraft, his patience and labour would have been writ in water without children to succeed him and carry on the work which he had begun; and at times it seemed probable that this necessary condition would remain unfulfilled. For the Tudors were singularly luckless in the matter of children. They were scarcely a sterile race, but their offspring had an unfortunate habit of dying in childhood. It was the desire for a male heir that involved Henry VIII. in his breach with Rome, and led Mary into a marriage which raised a revolt; the last of the Tudors perceived that heirs might be purchased at too great a cost, and solved the difficulty by admitting its insolubility. Henry VIII. had six wives, but only three children who survived infancy; of these, Edward VI. withered away at the age of fifteen, and Mary died childless at forty-two. By his two[27] mistresses he seems to have had only one son, who died at the age of eleven, and as far as we know, he had not a single grandchild, legitimate or other. His sisters were hardly more fortunate. Margaret's eldest son by James IV. died a year after his birth; her eldest daughter died at birth; her second son lived only nine months; her second daughter died at (p. 013) birth; her third son lived to be James V., but her fourth found an early grave. Mary, the other sister of Henry VIII., lost her only son in his teens. The appalling death-rate among Tudor infants cannot be attributed solely to medical ignorance, for Yorkist babies clung to life with a tenacity which was quite as inconvenient as the readiness with which Tudor infants relinquished it; and Richard III., Henry VII. and Henry VIII. all found it necessary to accelerate, by artificial means, the exit from the world of the superfluous children of other pretenders. This drastic process smoothed their path, but could not completely solve the problem; and the characteristic Tudor infirmity was already apparent in the reign of Henry VII. He had three sons; two predeceased him, one at the age of fifteen years, the other at fifteen months. Of his four daughters, two died in infancy, and the youngest cost the mother her life.[28] The fruit of that union between the Red Rose and the White, upon which so much store had been set,[29] seemed doomed to fail.