The contest of Christianity with Mahometanism, so far as it has been a struggle of argument and not of the sword, offers few remarkable points. In the first sweep of the Mahometan conquest, when the Christian nations succumbed both in the east and west, there was no field for a question of truth. It was only in Christian nations which were removed from peril, and yet sufficiently in contact to entertain the question of the claims of the Mahometan religion, that a consideration of its nature, regarded as a system of doctrine, could arise. Accordingly it is in Constantinople, or in Spain and the other parts of western Europe which came into connexion with the Moors, that works of this character appear. The history may be conveniently arranged in three periods, each of which is marked by works of defence, some called forth by danger, a real demand, but subsiding into or connected with inquiries prompted only by literary tastes. The first is from the twelfth to the middle of the sixteenth century; the second during the seventeenth and eighteenth; the third during the present century. 1. A notice of the Mahometan religion exists in a work of J. Damascenus, in the eighth century; and Euthymius Zigabenus, a Byzantine writer of the twelfth: but the first important treatise written directly against it was in 1210, _Richardi Confutatio_, edited in 1543 by Bibliander from a Greek copy. The refutation of Averroes by Aquinas, about 1250, can hardly be quoted as an instance of a work against the Mahometan religion, being rather against its philosophy. A treatise exists by John Cantacuzene, written a little after 1350; which is to be explained probably by the circumstance that the danger from Mahometan powers in the east directed the attention of a literary man to the religion and institutions which they professed. Thus far the works were called forth by a real demand. A series of treatises however commences about the time of the expulsion of the Moors from Spain, the cause of the existence of which is not so easy of explanation. Such are those in Spain by Alphonso de Spina, 1487, and by Turrecremata (see Eichhorn’s _Gesch. der Lit._ vi.); by Nicholas de Cuza, published in 1543; in Italy about 1500 by Ludovicus Vives, and Volterranus; one by Philip Melancthon in reference to the reading of the Koran; and a collection of treatises, including those of Richardus, Cantacuzene, Vives, and Melancthon, published by Bibliander in 1543. Probably the first two of this list may have been the relic of the crusade of Christianity against the Moorish religion; the next two possibly were called forth by the interest excited in reference to Mahometans by reason of their conquests, or less probably by the influence of their philosophy at Padua (see Lect. III. p. 100 seq.). The two last are hardly to be explained, except by supposing them to be an offshoot of the Renaissance, and called forth by the largeness of literary taste and inquiry excited by that event.