The most effective of them all was his “Guide for Sinners,” first published in 1556. It makes two moderate volumes, and portions of it are marked with a diffuse declamation, which is perhaps imitated from that of Juan de Avila, the Apostle of Andalusia, whose friend and follower he more than once boasts himself to have been. But its general tone is that of a moving and harmonious eloquence, which has made it a favorite book of devotion in Spain ever since it first appeared, and has spread its reputation so widely, that it has been translated into nearly all the languages of Europe, including the Greek and Polish, and, at one time, seemed likely to obtain a place, in the religious literature of Christendom, very near that of the great ascetic work which passes under the name of Thomas à Kempis. In its native country, however, the Guide for Sinners encountered at first not a little opposition. As early as the year after it was published, it had been placed on the Index Expurgatorius, and no edition except the first seems to have been permitted till we find that of Salamanca, in 1570. But the very Index that condemned it became itself the subject of condemnation; and, in the case of the Guide for Sinners, the ecclesiastical powers went so far in the opposite direction as to grant special indulgences by proclamation to all who should have read or heard a chapter of the very work they had earlier so harshly censured. Luis de Granada passed all the latter part of his life in Lisbon,--perhaps because he had been repeatedly annoyed by the Inquisition at home, perhaps because his duties seemed to lead him there. But, whatever may have been the cause, it is certain that he enjoyed much more favor in Portugal than he did in Spain; and when he died, in 1588, eighty-four years old, he could boast that he had refused the highest honors of the Portuguese Church, and humbly devoted the whole of his long life to the reformation and advancement of the Order of Preachers, of which, during his best years, he had been the active and venerated head.[237] [237] Preface to Obras de Luis de Granada, Madrid, 1657, folio, and Preface to Guia de Pecadores, Madrid, 1781, 8vo. Antonio, Bib. Nov., Tom. II. p. 38. Llorente, Hist., Tom. III. p. 123. His works are numerous, and he enjoys the singular honor of having had an edition of them published by Planta, at the expense of the Duke of Alva, the minister and general of Philip II.