The Comstocks also obviously had some medical tradition in their family. Samuel's younger brother, John Lee Comstock, was trained as a physician and served in that capacity during the War of 1812--although he was to gain greater prominence as a historian and natural philosopher. All five of Samuel's sons participated at least briefly in the drug trade, while two of them also had careers as medical doctors. A cousin of Edwin, Thomas Griswold Comstock (born 1829), also became a prominent homeopathic physician and gynecologist in St. Louis.[1] It might also be significant that the original home of the Comstock family, in Connecticut, was within a few miles of the scene of the discovery of the first patent medicine in America--Lee's "Bilious Pills"--by Dr. Samuel Lee (1744-1805), of Windham, sometime prior to 1796.[2] This medicine enjoyed such a rapid success that it was soon being widely imitated, and the Comstocks could not have been unaware of its popularity. So it seems almost certain that Edwin was no longer a novice when he established his own drug business in New York City. Between 1833 and 1837 he employed his brother, Lucius S. Comstock (born in 1806), as a clerk, and for the next fifteen years Lucius will figure very conspicuously in this story. He not merely appended the designation "M.D." to his name and claimed membership in the Medical Society of the City of New York, but also described himself as a Counsellor-at-Law. Edwin, the founder of the business, did not live long to enjoy its prosperity--or perhaps we should say that he was fortunate enough to pass away before it experienced its most severe vicissitudes and trials. After Edwin's death in 1837, Lucius continued the business in partnership with another brother, Albert Lee, under the style of Comstock & Co. Two more brothers, John Carlton (born 1819) and George Wells (born 1820), were employed as clerks. [Footnote 1: _National Cyclopedia of American Biography_, VII: 280.] [Footnote 2: The Comstock brothers' grandmother, Esther Lee, was apparently unrelated to Dr. Samuel Lee, the inventor of the Bilious Pills.] [Illustration: FIGURE 1.--Original wrapper for Carltons Liniment, 1851.] The partnership of Comstock & Co. between Lucius and Albert was terminated by a dispute between the two brothers in 1841, and Albert went his own way, taking up a career as a physician and living until 1876. Lucius next went into business with his mother-in-law, Anne Moore, from 1841 to 1846; after the dissolution of this firm, he formed a new partnership, also under the name of Comstock & Co., with his brother John (generally known as J. Carlton). This firm again employed as clerks George Wells Comstock and a nephew, William Henry, a son of Edwin. William Henry was to eventually become the founder of the business at Morristown.