Governor Lewis had, from early life, been subject to hypochondriac affections. It was a constitutional disposition in all the nearer branches of the family of his name, and was more immediately inherited by him from his father. They had not, however, been so strong as to give uneasiness to his family. While he lived with me in Washington I observed at times sensible depressions of mind: but knowing their constitutional source, I estimated their course by what I had seen in the family. During his western expedition, the constant exertion which that required of all the faculties of body and mind, suspended these distressing affections; but after his establishment at St. Louis in sedentary occupations, they returned upon him with redoubled vigour, and began seriously to alarm his friends. He was in a paroxysm of one of these, when his affairs rendered it necessary for him to go to Washington. He proceeded to the Chickasaw Bluffs, where he arrived on the sixteenth of September, 1809, with a view of continuing his journey thence by water. Mr. Neely, agent of the United States with the Chickasaw Indians, arriving there two days after, found him extremely indisposed, and betraying at times some symptoms of a derangement of mind. The rumours of a war with England, and apprehensions that he might lose the papers he was bringing on, among which were the vouchers of his public accounts, and the journals and papers of his western expedition, induced him here to change his mind, and to take his course by land through the Chickasaw country. Although he appeared somewhat relieved, Mr. Neely kindly determined to accompany and watch over him. Unfortunately, at their encampment, after having passed the Tennessee one day's journey, they lost two horses, which obliging Mr. Neely to halt for their recovery, the governor proceeded, under a promise to wait for him at the house of the first white inhabitant on his road. He stopped at the house of a Mr. Grinder, who not being at home, his wife, alarmed at the symptoms of derangement she discovered, gave him up the house and retired to rest herself in an out-house, the governor's and Neely's servants lodging in another. About three o'clock in the night he did the deed which plunged his friends into affliction, and deprived his country of one of her most valued citizens, whose valour and intelligence would have been now employed in avenging the wrongs of his country, and in emulating by land the splendid deeds which have honoured her arms on the ocean. It lost too to the nation the benefit of receiving from his own hand the narrative now offered them of his sufferings and successes, in endeavouring to extend for them the boundaries of science, and to present to their knowledge that vast and fertile country, which their sons are destined to fill with arts, with science, with freedom and happiness.