Fortune, however, had changed sides since the time of Antiochus the Great, and no longer favored the Seleucidæan dynasty. Antiochus lost his life in this campaign, and his brother Demetrius, who had been set at liberty by the king of Parthia at the time of the invasion of Antiochus, to be opposed to him as a rival monarch, now reigned in his brother's stead (from 128-125). Hated by the Syrians on account of his long imprisonment in Parthia, Demetrius was opposed by a rival, Alexander Zabina, whom Ptolemy Physcon had set up against him. Demetrius was obliged to flee before Zabina, and could not even find a refuge in Accho, where his wife Cleopatra resided. Syria fell into a state of still greater confusion under his successors, when Zabina disputed the throne with the legitimate heir, Antiochus VIII, the latter finding likewise a competitor in his brother on the mother's side, Antiochus IX. The last pages of the history of Syria are stained with crimes caused by the deadly hatred of the various members of the Seleucidæan house against each other, and with the murders they committed. Soon after the death of her husband Demetrius, Cleopatra had one of her sons, Seleucus, killed, and mixed the poisoned cup for the other one, Antiochus Grypus, who forced her to drink it herself. Hyrcanus took advantage of this state of anarchy and weakness in Syria, which lasted several years, to enlarge the boundaries of Judæa, until his country attained its former limits. Soon after the death of Antiochus Sidetes, the last traces of vassalage to which the siege of Jerusalem had reduced Judæa were completely wiped out, and even the bonds of alliance were canceled, whilst Alexander Zabina was grateful to be acknowledged by Hyrcanus as king of Syria. It was at this period (124) that the inhabitants of Jerusalem, particularly those included in the great council, made an appeal to the Egyptian community and to the priest, Judas Aristobulus, teacher to the king, and of priestly lineage, to allow the anniversaries of the consecration of the Temple and of the victory over the sinners to be numbered among the memorial holidays of the nation. To strengthen their request they referred to the unexpected help which God had given His people in the evil days of Antiochus, enabling them to restore the sanctuary to its former purity. This appeal from Judæa was at the same time a hint to the Alexandrian community to acknowledge the new conditions that had arisen.