The sisters appear to have been nurses, for there is no mention made of any leprous sister. The chapel of the hospital appears from King Henry II.'s charter to have been built on the site of some older parochial church. The Bull of Pope Alexander mentions that the hospital wall enclosed eight acres. Within this triangular space, which is at present roughly bounded by the High Street, Charing Cross Road, and Shaftesbury Avenue, was one central building or mansion for the lepers, several subordinate buildings, the chapel, and the gate-house. Whether the number of lepers was reduced when the hospital possessions were curtailed we are not told. After the hospital buildings fell into the hands of Lord Dudley they underwent many changes. The principal building he converted into a mansion for his own use; this was the manor-house. It stood between the present Denmark Street and Lloyd's Court, and its site is occupied by a manufactory. After two years Lord Dudley obtained from the King license to transfer all his newly-gained estates to Sir Wymonde Carew, but there seems reason to suppose that Lord Dudley remained in possession of the manor-house until his attainder in the reign of Queen Mary, because the manor then reverted to the Crown, and was regranted. Clinch gets out of this difficulty by supposing Lord Dudley to have parted with his estates and retained the manor, but in the deed of license for exchange all his "mansion place and capital house, late the house of the dissolved hospital of St. Giles in the Fields," is especially mentioned. It is possible that Sir Wymonde leased it again to the Dudley family. Among the many subsequent holders of the manor we find the name of Sir Walter Cope, who bought the Manor of Kensington in 1612, and through whose only child, Isabel, it passed by marriage to Sir Henry Rich, created Earl of Holland. The Manor of St. Giles was in the possession of the Crown again in Charles II.'s reign, when Alice Leigh, created by him Duchess of Dudley, lived in the manor-house. This Duchess made many gifts to the church, among which was a rectory-house.