First, then, as to the effects of suggestion on the vaso-motor system. Simple effects of this type form the commonest of "platform experiments." The mesmerist holds ammonia under his subject's nose, and tells him it is rose-water. The subject smells it eagerly, and his eyes do not water. The suggestion, that is to say, that the stinging vapour is inert has inhibited the vaso-motor reflexes which would ordinarily follow, and which no ordinary effort of will could restrain. _Vice versâ_, when the subject smells rose-water, described as ammonia, he sneezes and his eyes water. These results, which his own will could not produce, follow on the mesmerist's word. No one who sees these simple tests applied can doubt the genuineness of the influence at work. We find then, as might be expected, that action on glands and secretions constitutes a large element in hypnotic therapeutics. The literature of suggestion is full of instances where a suppressed secretion has been restored at a previously arranged moment, almost with "astronomical punctuality." And yet to what memory is that command retained? by what signal is it announced? or by what agency obeyed? In spite of this underlying obscurity, common to every branch of suggestion, these vaso-motor phenomena are by this time so familiar that no further description of them is necessary. This delicate responsiveness of the vaso-motor system has given rise to some curious spontaneous phenomena, and has suggested some experiments, which are probably as yet in their infancy. The main point of interest is that at this point spontaneous self-suggestion, and subsequently suggestion from without, have made a kind of first attempt at the modification of the human organism in what may be called fancy directions,--at the production of a change which has no therapeutic aim, and so to say, no physiological unity; but which is guided by an intellectual caprice along lines with which the organism is not previously familiar. I speak of the phenomenon commonly known as "stigmatisation," from the fact that its earliest spontaneous manifestations were suggested by imaginations brooding on the stigmata of Christ's passion;--the marks of wounds in hands and feet and side. This phenomenon, which was long treated both by _savants_ and by devotees as though it must be either fraudulent or miraculous,--_ou supercherie, ou miracle_,--is now found (like a good many other phenomena previously deemed subject to that dilemma) to enter readily within the widening circuit of natural law. Stigmatisation is, in fact, a form of vesication; and suggested vesication--with the quasi-burns and real blisters which obediently appear in any place and pattern that is ordered--is a high development of that same vaso-motor plasticity of which the ammonia-rose-water experiment was an early example.[81]