=Longevity= is diminished by immoderate indulgence in alcohol. The statistics of Temperance Insurance Societies, show much better results among teetotalers than among moderate drinkers. It is only fair to add that although the latter are supposed to consist of moderate drinkers—and particular enquiries are always made on this point before insurance—it is probable that a large proportion of them exceed 1½ ounces of alcohol per day. Making due allowance for this fact, the statistics show a great superiority in the expectation of life of teetotalers. =Factors Modifying the Effects of Alcohol.=—1. =Age and Sex.=—Until adult life is reached, total abstinence from alcohol should be enforced. The delicate nervous system of children is easily disturbed by it, and it appears in some measure to retard growth. Another argument against giving alcohol before adult age is reached, is still more important. It is at this period of life that habits are chiefly formed, and a craving for alcohol may be insidiously produced, destined to have most baneful results. Old people, if ordered spirits for medical reasons, should drink them well diluted. Women are much more easily affected by alcohol than men, and if they acquire the habit of excess, the hope of reformation is even less than with men. 2. =Exercise= has a most important influence in modifying the effects of alcohol. Those of sedentary occupations and living in towns, cannot oxidise as much as those engaged in active out-door work, and are consequently much more prone to suffer. A game-keeper in the Scotch Highlands may possibly live to a good old age, notwithstanding the fact that he consumes an amount of whiskey that would have sent a sedentary man to his grave in the course of a few years. 3. =The Condition of the Stomach= has also great influence. When the stomach is empty, alcohol produces at once a powerful reflex stimulation of the heart, and becomes quickly absorbed into the circulation. Thus intoxication may be produced by a quantity that would have had little effect if taken with a meal. 4. =The State of Concentration or Dilution= modifies greatly the action of alcohol, the local action on the stomach and the reflex stimulation being much greater than when it is concentrated, and injurious effects being much more likely to occur.