5. =Cold and Heat= modify the action of alcohol. A smaller quantity of hot spirits and water will intoxicate than of cold; the heat stimulating the heart, and so making the absorption of the alcohol more rapid. A glass of hot spirits and water will often cause sleep, by drawing the blood towards the abdominal organs. The fact that persons, who have been drinking spirits in a warm room, on going out into the cold air become suddenly intoxicated, seems opposed to what has been already said. But probably this is due to the cold causing contraction of the arteries of the skin, and so driving more of the blood loaded with alcohol to the internal organs and the brain (Brunton). 6. =Mental Occupation= has some influence in modifying the effects of alcohol. Topers have found that if they try to converse during their debauch—the conversation implying increased functional activity of the brain, and therefore a freer circulation of blood in it—intoxication occurs much more readily, than when the mind is not active. 7. =Disease= modifies greatly the effects of alcohol. In some diseases, as in inflammation of the lungs and in fevers, it can be given in large quantities without producing intoxication; and in these conditions it lowers the temperature. In other diseases, especially gout and kidney disease, its use is nearly always followed by bad results. =The Advisability of Alcohol as an Article of Diet in Health.=—In dealing with this difficult point, two sets of facts require consideration, those obtained as the result of =Physiological= observations (see page 56), and those which are the result of =Experience=. There can be no doubt that the former are much more reliable than the latter. Experience is very prone to give fallacious results, especially when questions of appetite are concerned. In making a trial of abstinence, the mistake has been commonly made of only prolonging the investigation for a few weeks, and then comparing results. Such a method is, however, very unfair, and is certain to lead to an unreliable conclusion. The records of experience under certain conditions have, however, been so extensive, as to lead to trustworthy results. It has been abundantly proved that prolonged muscular work is best undergone during total abstinence from alcohol; and that the extremes of heat and cold and the exposure and exertions of marching armies, are best borne under similar conditions. The artificial character of town life is commonly adduced as an argument for the moderate use of alcohol. In the case of healthy workers, this does not hold good; many of our hardest workers and thinkers take no alcohol. The universality of the habit of taking stimulants is a curious argument on the same side, though if the habit be bad, this can be no more reason for continuing it than can the prevalence of vice be an excuse for indulgence in it.