Not every individual acquires influenza. There are those who assume that the disease is so wide spread that every individual in each community attacked has been actually exposed to the disease. In that case there must be a certain amount of natural immunity which protects around sixty to eighty per cent. of most populations from the disease. The other extreme would be that every exposed individual falls victim to the disease and that only twenty to thirty or forty per cent. are actually exposed. The true state probably lies between these two extremes. Nevertheless it is a fact that some individuals naturally insusceptible to the disease fall victim as a result of the action of some extraneous force, something which lowers their resistance. Raw recruits in the army camps in the fall of 1918 contracted the disease in much greater proportion than did the hardened soldiers. Fatigue, intercurrent illness, environmental changes and exposure to inclement weather may all predispose to infection in the individual. Greenwood found that the compulsory rationing of food in England during the war was probably not a predisposing cause of infection. The incidence of the disease in the South Africa Union where food was abundant was even higher than that for the British Isles. Hamer calls attention to the fact that the ages of highest incidence during the pandemic were those ages in which the diet was perhaps more restricted than in other ages. This, however, is but one factor and cannot be accepted as conclusive. It had been suggested that in the army camps in the United States typhoid vaccination during the epidemic predisposed to the disease. The similarity of the symptoms in vaccine reaction and in influenza may have suggested this. V. C. Vaughan has investigated this possibility and finds that those organizations in which anti-typhoid vaccine was discontinued for a time after the appearance of the influenza suffered quite as severely as those which submitted to vaccination. Other predisposing causes, such as the incidence of crowding in a household and the sanitary surroundings of the individual will be discussed later. PERIODICITY. The phenomenon of occurrence of epidemic influenza in many countries, even on different continents almost simultaneously and often without any clearcut progressive spread from one of these countries to another raises the question of periodicity in influenza. Is this simultaneous occurrence due to some mechanism in the life cycle of the influenza virus whereby it regularly acquires increased invasiveness, no matter what its geographical distribution, or is it merely a feature of the meteorologic conditions that makes the epidemic appear to be simultaneous in widely scattered communities?