─────┼──────────────┼─────────────┼──────────────┼───────────────┼────────────── 1557│All of Europe.│Conflicting │General │Asia, │4 months from │ │information │direction from│Constantinople,│Italy to │ │(Asia?). │South to North│Sicily, Italy, │Netherlands. │ │ │in Europe. │Spain, │Sicily in │ │ │ │Dalmatia, │June. Nimes in │ │ │ │Switzerland, │July. Italy in │ │ │ │France, │August. Madrid │ │ │ │Netherlands, │in August. │ │ │ │England. │Dalmatia in │ │ │ │ │September. │ │ │ │ │Netherlands in │ │ │ │ │October. ─────┼──────────────┼─────────────┼──────────────┼───────────────┼────────────── 1562│Uncertain │ │Only small │ │ 1563│information. │ │epidemics at │ │ │ │ │most. │ │ ─────┼──────────────┼─────────────┼──────────────┼───────────────┼────────────── 1580│True pandemic │Orient │From Asia to │Orient, North │France in May. │covering the │(Hirsch) │Constantinople│Africa, │Germany and │Orient, Africa│Africa and │and in Europe │Constantinople,│Hungary in │and Europe. │Malta │from South to │Malta, Venice, │August. │ │(Pechlin). │North. │Sicily, Italy, │England and │ │ │ │Spain, Hungary │Rhine Valley │ │ │ │and Germany to │in September. │ │ │ │the Baltic, │Saxony in │ │ │ │Bohemia, │October. │ │ │ │France, │ │ │ │ │Belgium, │ │ │ │ │England, │ │ │ │ │Denmark, │ │ │ │ │Sweden. │ ─────┼──────────────┼─────────────┼──────────────┼───────────────┼────────────── 1587│Apparently │ │ │Described in │ │quite │ │ │Italy and │ │localized. │ │ │Germany. │ ─────┼──────────────┼─────────────┼──────────────┼───────────────┼────────────── 1591│High │ │ │ │ │mortality. │ │ │ │