Influenza : $b An epidemiologic studyVaughan, Warren T. (Warren Taylor)
History
Influenza : $b An epidemiologic study
Vaughan, Warren T. (Warren Taylor)
Influenza
The state of our knowledge of influenza and tuberculosis is considerably
clouded by divergent opinions such as those quoted above. To further
complicate the picture, there are other authors who assume a middle
ground and believe that there is some truth in both lines of contention.
Thus, Amelung believes that the morbidity among patients with pulmonary
tuberculosis is slight, and that the grip takes a milder course in such
patients than in the nontuberculous, unless the disease is far advanced,
but that pulmonary tuberculosis may and sometimes does follow the
disease in patients whose lungs were previously sound, and that in the
last mentioned cases the prognosis is relatively bad. Peck finds that in
some tuberculous patients the disease has been aggravated, but in the
majority the intercurrent influenza did not appear to have been the
causative factor in the acute exacerbation of the tuberculosis.
Debré and Jacquet have reviewed the European literature on the subject
pro and con, and though they admit that there are exceptions, as at
l’hôpital Tenon, where, in a barracks reserved entirely for female
tuberculosis patients there was a veritable epidemic of grip, 29 per
cent. of the twenty-eight being attacked in a few days; and at the
sanatorium de La Tronche, where 83 per cent. took ill between the 25th
of September and the 20th of October; they conclude that as a rule
tuberculous individuals are less heavily attacked by the influenza than
are the nontuberculous. As they suggest, the first explanation that
comes to mind is that the tuberculous are isolated in the hospitals
where general hygienic conditions are good, but we have all seen other
institutions, hospitals, etc., in which the inmates were not spared as
they were in tuberculosis hospitals. Furthermore, in certain sanatoria,
such as the sanatorium of the Côte Saint-André, and Bligny, and several
German sanatoria, the proportion of tuberculous individuals attacked was
very much less than that of the professional attendants, the physicians
and nurses. Again, where cases have occurred in these hospitals, and
little precaution was taken to prevent its spread, very few other
individuals took sick. Finally, many have noted the infrequency of the
disease even in those tuberculous individuals who were living at home.
It has been suggested that rest in bed from the beginning of the attack
explained the mildness, or that the immunity resulting from the
infection with pneumococcus, streptococcus, etc., in tuberculous
individuals explained the absence of pulmonary complications. Marfan,
who observed this same phenomenon in 1890, suggested that it might be
due to a refractory state of the tubercle bacillus against the virus of
influenza. Debré and Jacquet conclude that none of these explanations is
satisfactory.
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