Irritability : $b a physiological analysis of the general effect of stimuli in living substanceVerworn, Max
Science
Irritability : $b a physiological analysis of the general effect of stimuli in living substance
Verworn, Max
Irritability
of the narcotized stretch of the nerve plays an important rôle in the
obliteration of conductivity. It has been found by the application
of a stimulus above the narcotized stretch of nerve, that the longer
this stretch is, the less is the reduction of irritability which
obliterates the excitation wave reaching this area. Further: The
shorter the stretch, the greater must be the reduction in irritability
before this result is brought about. (Figure 22.) In other words, the
conductivity in the narcotized nerve is dependent upon the length and
the irritability of the narcotized stretch. From this observation the
important fact is evolved, that the wave of excitation meets with a
decrement of its intensity in the narcotized area. This decrement
becomes larger as the wave progresses through the involved stretch.
Further it is progressively increased as the amount of the irritability
is reduced. Finally, when the stretch is long enough, the wave of
excitation is obliterated. This important fact has been further
established by the experiments of _Boruttau_ and _Fröhlich_,[107] in
which they studied the intensity of the current of action, produced by
a wave of excitation, from two points in the narcotized stretch. The
wave of negative variation, brought about by the excitation, gradually
decreases in the narcotized stretch as the electrode is further removed
from the point of entrance. Beside a decrement of _intensity_, as
the investigations of _Fröhlich_[108] prove, the wave of excitation
shows a decrement of the velocity in the narcotized stretch. And it
is probable that the wave of excitation extends with _progressive_
reduction in the velocity, corresponding to the decrement of intensity.
The work of _Koike_[109] under the direction of _Garten_, in which the
conclusion arrived at is that the reduction in the velocity is the same
throughout the narcotized area, should not be accepted as conclusive
in spite of the delicate method employed. These investigations are
extremely difficult, being in the field of the most delicate of
present-day methods. The decrement, which the wave of excitation meets
with in its progress in the narcotized stretch, makes the conflicting
testimony concerning the apparent separation of irritability and
conductivity intelligible. It depends entirely upon the length of
the narcotized area, and the amount of reduction in irritability on
the one hand, and the strength of the stimulus used for testing the
irritability on the other, whether the conductivity will disappear
_before_ the irritability or _vice versa_. If I test the irritability
in the narcotized stretch with a weak stimulus, just slightly _above_
the threshold, then by slight reduction in the irritability complete
absence of response occurs, when the same stimulus is applied. This
occurs at a time when excitation reaches the narcotized area from
above and meets with a decrement so slight that it can pass through
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