Irritability : $b a physiological analysis of the general effect of stimuli in living substanceVerworn, Max
Science
Irritability : $b a physiological analysis of the general effect of stimuli in living substance
Verworn, Max
Irritability
We have already seen that the wave of excitation meets with a decrement
of its intensity in the narcotized stretch, which increases in
strength as the irritability diminishes. If the value of the threshold
is learned by stimulating the nerve at the electrodes centrally placed
to the chamber with minimal stimuli, it would necessarily follow that
this weak stimulus would bring about a corresponding weak excitation
of the individual fibers and the wave of excitation already in the
beginning of narcosis would be obliterated, for it would meet with a
decrement, the result of the reduction in the irritability. A wave of
excitation of minimal strength could under these conditions no longer
reach the muscle, even in the beginning of narcosis. In spite of this
the excitation, even when produced with threshold stimuli, passes
through for a long time, even when the irritability in the chamber is
greatly reduced, as shown by testing with the electrodes within the
chamber. This is not consistent with the assumption that a threshold
stimulus brings about the minimal excitation, even in the individual
nerve fiber. But further: with a definite decrease of irritability of
the narcotized stretch the capability of conductivity disappears, and
indeed simultaneously for the weakest as well as the strongest stimuli.
If it is assumed that weak stimuli bring about weak excitations in the
nerve fiber, it must most certainly be expected that on the cessation
of the response, weak stimuli applied at the central nerve end would
still, by slight increase of the intensity of stimulation, be followed
anew by reaction in the muscle. This is all the more to be expected,
because the irritability of the narcotized stretch, as shown by
stimulation with the electrodes inside the chamber, very gradually
decreases, so that within the chamber stimuli of moderate strength are
still effective. Instead the capability of conduction is completely
obliterated, and even the strongest stimuli, applied to the end of
the nerve, produce no response in the muscle. This in turn does not
agree with the assumption that the intensity of excitation varies with
the strength of the stimulus in the individual nerve fiber. The facts
here alluded to are, therefore, either not correct, or the intensity
of excitation in the individual nerve fibers is independent of the
strength of the stimulus, and the view which we have entertained up to
the present in this respect is incorrect.
[Illustration: Fig. 24.]
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