Irritability : $b a physiological analysis of the general effect of stimuli in living substanceVerworn, Max
Science
Irritability : $b a physiological analysis of the general effect of stimuli in living substance
Verworn, Max
Irritability
In order to examine these facts once more on an extensive scale, and
at the same time obtain an understanding of the development of the
decrement in the narcotized stretch, I have requested _Dr. Lodholz_ to
register as many accurate curves as possible in which the positions of
the secondary coil of an inductorium are the ordinates indicating the
threshold of stimulation at four points of a nerve stretch. Of these
points three are situated at prescribed distances from each other in
the narcotized or asphyxiated stretch; the fourth is centrally placed.
(Figure 24.) As might be expected the result was the same as in former
investigations. They show however even more strikingly the abruptness
of the disappearance of conductivity simultaneously for the weakest
and the strongest stimuli. The curve produced by the centrally placed
electrode remains at the same height for a considerable period, then
suddenly abruptly declines. Those of the electrodes within the chamber
likewise sink, at first slowly, then with increasing rapidity in
successive order corresponding to the distance which they are situated
from the point of exit of the nerve, so that the curve of the most
distant electrode reaches the abscissa first, that of the electrode
nearest the muscle in the chamber, last. The experiments demonstrate
with complete clearness that in contrast to all those points within the
affected stretch, where the conductivity, though already obliterated
for weaker stimuli, still exists for stronger, that with stimulation
of a point towards the center _above_ the affected stretch, conduction
ceases simultaneously for all different strengths of stimuli. This
last state at the points within the affected stretch might be ascribed
to the diminution of the excitability of this stretch, and the idea
entertained that the weak stimuli no longer produce excitation capable
of further conduction.
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