Jaundice: Its Pathology and Treatment: With the Application of Physiological Chemistry to the Detection and Treatment of Diseases of the Liver and PancreasHarley, George
Science
Jaundice: Its Pathology and Treatment: With the Application of Physiological Chemistry to the Detection and Treatment of Diseases of the Liver and Pancreas
Harley, George
Jaundice
There are other substances besides gall-stones which, by their
accidental presence in the bile-ducts, may give rise to jaundice. Thus,
for example, foreign bodies, such as cherry-stones, have found their
way from the intestine into the bile-duct, and given rise to jaundice.
Intestinal worms have been observed to do the same thing, and recently
an interesting case of jaundice, occurring in a girl aged 16, who died
after a few weeks' illness, has been reported, which resulted from the
presence of hydatids in the ductus hepaticus, and ductus communis
choledochus.[17] Hydatids of the liver itself seldom give rise to
jaundice, their position being usually such as not to interfere with
the biliary function.
[Footnote 17: Dr. Dickinson has reported this case in the Pathological
Society's "Transactions," p. 104, vol. xiii. 1862.]
There are still other cases where we find {46} transient jaundice
arising from accidental obstruction of the bile-ducts; but in them,
instead of the closure of the ducts resulting from plugging from
within, it arises from the application of pressure from without. Thus,
for example, transient jaundice is met with as the result of closure of
the common bile-duct, by pressure exerted upon it by the pregnant
uterus, or by impacted fæces in the transverse colon. Certain permanent
abdominal tumours may also lead to the same result, but these will with
greater propriety be considered under the next head.
PERMANENT JAUNDICE FROM OBSTRUCTION.
In order to give as clear a view as possible of the pathology of
permanent jaundice from obstruction, it will be necessary for me to
give the history of a case of closure of the outlet of the common
bile-duct in consequence of organic disease--such, for example, as
cancer of the head of the pancreas. A case of this kind has the further
advantage of at the same time furnishing us with a typical example of
jaundice arising from the re-absorption of the secreted, but retained
bile.
When cancer of the head of the pancreas involves the orifice of the
common bile-duct, as the tumour grows, the duct slowly, and gradually
becomes impervious to the passage of bile into the {47} intestines,
until at length the flow is completely arrested. As this gradual
process of occlusion of the outlet goes on, the duct itself becomes
more and more distended by the retained bile, till it at length attains
an enormous size. The gall-bladder being equally prevented from
emptying itself, likewise becomes stretched and dilated, until it may
at last become not only palpable to the touch, but even apparent to the
eye through the abdominal walls. This was the case in the patient whose
liver, and occluded ducts are represented in Plate I.
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