Descartes has clearly stated what he conceived to be the difference between spirit and matter. Matter is substance which has extension, but does not think; spirit is substance which thinks, but has no extension. It is very hard to form a definite notion of what this phraseology means, when it is taken in connexion with the location of the soul in the pineal gland; and I can only represent it to myself as signifying that the soul is a mathematical point, having place but not extension, within the limits of the pineal gland. Not only has it place, but it must exert force; for, according to the hypothesis, it is competent, when it wills, to change the course of the animal spirits, which consist of matter in motion. Thus the soul becomes a centre of force. But, at the same time, the distinction between spirit and matter vanishes; inasmuch as matter, according to a tenable hypothesis, may be nothing but a multitude of centres of force. The case is worse if we adopt the modern vague notion that consciousness is seated in the grey matter of the cerebrum, generally; for, as the grey matter has extension, that which is lodged in it must also have extension. And thus we are led, in another way, to lose spirit in matter. In truth, Descartes' physiology, like the modern physiology of which it anticipates the spirit, leads straight to Materialism, so far as that title is rightly applicable to the doctrine that we have no knowledge of any thinking substance, apart from extended substance; and that thought is as much a function of matter as motion is. Thus we arrive at the singular result that, of the two paths opened up to us in the "Discourse upon Method," the one leads, by way of Berkeley and Hume, to Kant and Idealism; while the other leads, by way of De La Mettrie and Priestley, to modern physiology and Materialism.[76] Our stem divides into two main branches, which grow in opposite ways, and bear flowers which look as different as they can well be. But each branch is sound and healthy, and has as much life and vigour as the other.