The compound under investigation was carefully weighed out each day (0·5 to 1·0 gramme), the substance being some of the same compound that was being made use of for inhalation experiments. In the case of the white lead it was found essential to mix it with the animals’ food; they were given white lead in a small amount of their food, and no further food was given for some little time after the dose of lead had been swallowed. Low and high solubility glazes were also made use of for feeding, and as a further experiment alcohol was given to the animals in addition to the previous course of lead inhalation or feeding, and the exposure to lead continued after the alcohol was given. In addition to high solubility glazes, white lead, and flue dust, a soluble salt of lead was also used, in one series the salt being the nitrate. 0·1 gramme was given daily; and it is these two nitrate animals (46 and 47) which showed distinct differences from the white lead and other feeding experiments. In one case the lead was given mixed with water, in the other mixed with milk. The animal which was fed with the nitrate dissolved in water developed encephalopathy, whereas the one in which the substance was mixed in milk exhibited no signs, though fed for a similar period. Both the animals increased in weight, which is an unusual effect in experimental lead poisoning. The question of the addition of milk, which apparently prevented the absorption of lead, is of very considerable importance, as it is highly probable, as has been pointed out with regard to the precipitation of lead by means of organic substances, that the albuminoid substances in the milk precipitate the nitrate already in a state of solution; and it may be argued from these experiments that mixing the white lead with the food would tend to prevent the lead having a toxic or deleterious effect, but even when the lead was given in the form of pills between meals no poisonous effect was noticed. Further, the quantity of white lead given was considerable, and it is highly questionable whether the quantity of lead so taken would be dissolved by the gastric juice excreted under normal circumstances in its entirety, as a very considerable quantity would pass onwards through the pylorus undissolved. Until the lead compound has become soluble it cannot react with the albuminoid constituent of the food. Ordinary dry white lead or litharge does not combine directly with albumin.