The majority of the experimental animals showed alteration in weight. The most important point which is brought out by these experiments, considering them from the point of view of inhalation, is the enormous quantity of white lead the “feeding” animals swallowed without producing any apparent symptoms. The quantities cited are the amounts given per diem, whereas in the inhalation experiments the animals were rarely exposed more than three days a week for an hour at a time (see table, p. 101). The quantity of lead, therefore, given by the gastro-intestinal canal was at least ten times as much, in many cases fifteen or twenty times as much, as could be taken by the other animals via the lung during inhalation, and yet these animals showed little or no susceptibility to poisoning when fed with white lead or other lead compounds, unless alcohol was given in addition. An examination of the stomach after death showed, in the case of the alcoholic animals, distinct evidence of gastritis, and there is some reason to suppose that in such animals a degree of hyperacidity may have existed, thereby promoting the rate of solution of the lead. The increased susceptibility to lead poisoning through the agency of alcohol is interesting. No. 6 received, in addition to its inhalations or period of exposure in the dusty air, 50 c.c. of port wine per diem. Symptoms of lead poisoning appeared a day sooner than in any other animal, and if we eliminate this experiment, as the dust (flue dust from blast-furnace) contained also arsenic and antimony, three days sooner than the litharge animal, and twenty-five days sooner than the other animals exposed to white lead dust. In addition, this animal was the only one which actually died during the period of experiment; all the other animals were killed at the end of two months and submitted to histological examination; but the animal which had received alcohol died with symptoms closely simulating lead encephalopathy in man. The predisposing action of alcohol is still further emphasized by the subsequent experiments with three animals exposed to white lead dust; one was exposed thirty-seven and the other thirty days before symptoms appeared, whereas when alcohol was given poisoning was apparent within twelve days, and after only four inhalations.