In the case of animals fed with white lead, one after eight months, and the other a year and a half, showed no signs of lead poisoning at all, while the weights remained constant. At the end of this time alcohol (50 c.c. of port wine) was added to the animals’ diet, and one month after the addition of alcohol to the diet, the dose of white lead being continued constant, encephalopathy ensued. In a second case the animal was started on alcohol in addition to the white lead. In a month it was showing signs of slight paresis. Again, an animal fed on a low-solubility frit consisting of ground-up lead silicate, showed no ill-effects after receiving a daily dose of this compound. At the end of this time alcohol was added to its diet, and six months later the animal developed symptoms of cerebral involvement, which continued at intervals until a fatal attack of encephalopathy at the end of a year. There is thus definite evidence to show that the addition of alcohol to the animal’s diet undoubtedly hastened and determined the appearance of lead poisoning, and this, taken in conjunction with the inhalation experiments previously cited, is very strong evidence of the increased susceptibility to lead poisoning produced by alcohol. This supersensitiveness to lead through the medium of alcohol is a matter of clinical experience to most persons who have had experience of industrial lead poisoning, particularly those who have been engaged in the routine examination of persons working in factories. =Inoculation Experiments.=--In order to control both the feeding and the inhalation experiments, and more particularly to obtain direct information of the effect of lead upon the body tissues, resource was had to the inoculation of the various lead compounds tested--namely: (1) White lead, (2) litharge, (3) lead frit. These three compounds are the three types of lead salt which are used in the Potteries, whilst white lead and litharge are the compounds causing industrial poisoning in the largest proportion of cases in other industries. As a further control, the more soluble lead salts were also made use of--namely, acetate, nitrate, and chloride--mainly for the purpose of establishing some standard of poisoning both in rate and dose. Several rather unexpected results were derived from the inoculation experiments, which will be referred to. The method of inoculation was to suspend the lead compound to be tested in normal saline solution or distilled water. The animal was then shaved, and the lead compound inoculated into the muscles of the back. The corrosive action of these lead salts was avoided by using a considerable quantity of diluent.