The animal was emaciated, the fur easily pulled out, and the muscles were exceedingly flaccid. Rigor mortis was slow in making its appearance; the blood remained fluid for a considerable time. Practically no fat was to be found in the whole of the mesentery, and the omentum was devoid of fat and shrivelled. The fat around the kidneys had entirely disappeared. There was little orbital fat. The peritoneum was thin and glistening, and very frail. The whole of the mesenteric vessels, particularly in the region of the large intestine and the ileo-cæcal valve, were engorged with blood; whilst in the lower part of the small intestine, and often in the duodenum, occasionally in the whole of the jejunum and ileum, traces of minute hæmorrhages were found along the intestinal wall. The liver was engorged with blood, as was the spleen. The kidney capsule stripped easily, but was occasionally adherent here and there. The whole of the cortical vessels were injected with blood, the branching showing most distinctly. A good deal of serous fluid was at times found underneath the kidney capsule. On section the cortex appeared engorged with blood, and showed here and there, even to the naked eye, small hæmorrhages. In the region of the appendix a few large mesenteric glands were invariably found, whilst a few glands might also be found in the wasted mesentery of the small intestine. In the region of the appendix the glands were frequently dark in colour. On opening the gut, minute hæmorrhages and ulcerated patches were to be found in the lower part of the ileum; the ileo-cæcal valve, and the whole of the large intestine, extending right up to the end of the appendix, was covered with a dark slate-blue slime, in which lead could be easily recognized by chemical processes. Ulceration of the gastric mucous is uncommon, and only on one occasion were any hæmorrhages found. In the thoracic cavity the lungs were generally found to be emphysematous, and particularly in those animals subjected to inhalation of lead frit containing angular particles of lead glaze broncho-pneumonia was found. The heart was flabby, and occasionally distinct roughening and thickening of the valves was seen. _Nervous System._--On opening the skull, hæmorrhages were frequently found at the base of the brain, occasionally situated over the surface of the cerebrum. Minute hæmorrhages were found often underneath the arachnoid membrane, but the largest hæmorrhages were always found at the base of the brain, and spreading down into the spinal canal along the medulla. On removing the cord, minute hæmorrhages were found along the surface, irregular in distribution, and never very large. On section the brain and cord appeared normal. =Histology.=--A large number of sections were prepared from the animals developing symptoms of poisoning; the various tissues are described seriatim: