_Muscles._--These appear to have undergone general fatty degeneration. The individual muscle fibres are indistinct in outline, and show irregular areas stained by hæmatoxylin. Some infiltration may be seen here and there between the muscle fibres, and minute hæmorrhages are occasionally detected, the chief appearance being that of general atrophy. The heart muscle shows similar degeneration, and the tendency of the sarcolemma to break down and stain irregularly is apparent. In many areas the muscle fibres stain poorly, if at all. Occasionally minute hæmorrhages are found, passing between the muscle fibres. _Liver._--The hepatic cells show varied degeneration; the vessels passing between the cells are engorged with blood, the cells being frequently much distorted from their general arrangement, and here and there completely obliterated by small areas of exudation as well as actual hæmorrhages. _Spleen._--The parenchyma shows masses of irregular spaces filled with recently-shed blood; the individual cells show a granular degeneration, with occasional basophile staining, the general appearance being one of chronic congestion. Here and there cloudy swelling may be seen. _Intestine._--Sections across the small intestine show atrophy of the intestinal wall, slight degeneration of the muscular coats, with infiltration and minute hæmorrhages. _Large Intestine._--Here similar minute hæmorrhages are found, in no case large enough to be seen by the naked eye. Areas of necrotic tissue are also seen in which considerable quantities of lead sulphide particles are found. PLATE I [Illustration: FIG. 1.--SECTION OF LARGE INTESTINE OF ANIMAL POISONED BY INHALATION OF WHITE LEAD, SHOWING EXCRETION OF LEAD BY TISSUES. (STAINED EOSIN AND HÆMATOXYLIN.) × 250. The whole of the large intestine was stained black, the staining commencing at the ileo-cæcal valve. No staining is observable in the small intestine; the line of demarcation is sharp.] [Illustration: FIG. 2.--INTESTINAL ULCERATION IN TURPENTINE POISONING. (STAINED EOSIN AND HÆMATOXYLIN.) × 250.] [Illustration: FIG. 3.--SECTION OF ANTERIOR CRURAL NERVE FROM ANIMAL POISONED BY INHALATION OF WHITE LEAD DUST, SHOWING HÆMORRHAGE IN NERVE. (STAINED HÆMATOXYLIN AND EOSIN.) × 250. There was paralysis of the quadriceps extensor on the right side; the left leg was unaffected and the left anterior crural nerve was unaffected.] PLATE II [Illustration: FIG. 1.--SECTION OF LUNG OF ANIMAL EXPOSED TO INHALATION OF WHITE LEAD DUST, SHOWING MASS OF LEAD IN THE LUNG SUBSTANCE. (STAINED HÆMATOXYLIN AND EOSIN, AND TREATED WITH H₂S.) × 250.] [Illustration: FIG. 2.--LUNG OF ANIMAL EXPOSED TO TURPENTINE VAPOUR. (STAINED HÆMATOXYLIN AND EOSIN.) × 250.] [Illustration: FIG. 3.--LUNG OF ANIMAL EXPOSED TO INHALATION OF WHITE LEAD DUST, SHOWING CHRONIC INFLAMMATION WITH EXUDATION AND CAPILLARY LEAKAGE AND HÆMORRHAGE. (STAINED HÆMATOXYLIN AND EOSIN.) × 250.]