You may recollect that I intimated to you that there was some probability of my changing my situation before a great while. Matters are now in such a state that it becomes proper to inform you that I shall probably be offered the situation of botanist to the scientific exploring expedition, now fitting out for the South Sea by the United States government. This is to be a large expedition, consisting of a frigate, two brigs, a store-ship, and a schooner; it is to be absent about three years. It will sail possibly in the course of the winter, but very probably not until spring. The scientific corps will consist of several persons, in different departments of science, and the persons who will probably be selected are mostly my personal friends: two of them at least having been recommended at my suggestion. The quarters offered us, and the accommodations, will be ample and complete, and the pay will probably be considerable. We hope to obtain over $2500 per year. Had I room here I would write you further particulars, but this will do for the present. I ask whether, if everything is arranged in a satisfactory manner, you are willing and think it best that I should go. I think it not unlikely that the appointments will be made during the present month. A few days ago I was offered the professorship of chemistry and natural history in the college at Jackson, Louisiana (in the upper part of that State, near the Mississippi River), with a salary of $1500 per year. This I at once declined. I do not like the Southern States. Yours affectionately, A. GRAY. NEW YORK, November 21, 1836. No appointments are yet made in the scientific corps of the South Sea expedition. The difficulties as to the naval officers are only just settled. There are so many who wish to command that it is impossible to please them all. Captain Jones, the commander, is now in town, and I had the pleasure of seeing him this evening at the Astor hotel. He goes to Boston to-morrow to look after the two brigs fitting out at the navy yard there. The Secretary of the Navy has written me that when the appointments are made in the scientific corps, the chief naturalists will be called to Washington for a few days, for the distribution of duties among them. If the place for which I ask is given me, it is not unlikely that I may be in Washington early next month. I think you cannot expect E. and myself before about Thanksgiving Day, when if she should have recovered we shall have one reason more than usual for returning thanks to the Author of all good. You did not, it appears, think it a matter of sufficient consequence to say anything about my contemplated voyage; or to offer even an opinion about the matter. Perhaps you thought that, like most people, I only asked advice after I had made up my own mind; and you are not far from correct in this supposition. Still I should have been glad to know that you take some interest in the matter.