MY DEAR FRIEND: I have this moment received your letter of the 5th instant from Basle. I am very glad to find that your breast is relieved, though perhaps at the expense of your legs: for, if the humor be either gouty or rheumatic, it had better be in your legs than anywhere else. I have consulted Moisy, the great physician of this place, upon it; who says, that at this distance he dares not prescribe anything, as there may be such different causes for your complaint, which must be well weighed by a physician upon the spot; that is, in short, that he knows nothing of the matter. I will therefore tell you my own case, in 1732, which may be something parallel to yours. I had that year been dangerously ill of a fever in Holland; and when I was recovered of it, the febrific humor fell into my legs, and swelled them to that degree, and chiefly in the evening, that it was as painful to me as it was shocking to others. I came to England with them in this condition; and consulted Mead, Broxholme, and Arbuthnot, who none of them did me the least good; but, on the contrary, increased the swelling, by applying poultices and emollients. In this condition I remained near six months, till finding that the doctors could do me no good, I resolved to consult Palmer, the most eminent surgeon of St. Thomas's Hospital. He immediately told me that the physicians had pursued a very wrong method, as the swelling of my legs proceeded only from a relaxation and weakness of the cutaneous vessels; and he must apply strengtheners instead of emollients. Accordingly, he ordered me to put my legs up to the knees every morning in brine from the salters, as hot as I could bear it; the brine must have had meat salted in it. I did so; and after having thus pickled my legs for about three weeks, the complaint absolutely ceased, and I have never had the least swelling in them since. After what I have said, I must caution you not to use the same remedy rashly, and without the most skillful advice you can find, where you are; for if your swelling proceeds from a gouty, or rheumatic humor, there may be great danger in applying so powerful an astringent, and perhaps REPELLANT as brine. So go piano, and not without the best advice, upon a view of the parts. I shall direct all my letters to you 'Chez Monsieur Sarraxin', who by his trade is, I suppose, 'sedentaire' at Basle, while it is not sure that you will be at any one place in the south of France. Do you know that he is a descendant of the French poet Sarrazin?