Your letter has led me to think over vivisection (I wish some new word like anaes-section could be invented (He communicated to 'Nature' (September 30, 1880) an article by Dr. Wilder, of Cornell University, an abstract of which was published (page 517). Dr. Wilder advocated the use of the word 'Callisection' for painless operations on animals.) for some hours, and I will jot down my conclusions, which will appear very unsatisfactory to you. I have long thought physiology one of the greatest of sciences, sure sooner, or more probably later, greatly to benefit mankind; but, judging from all other sciences, the benefits will accrue only indirectly in the search for abstract truth. It is certain that physiology can progress only by experiments on living animals. Therefore the proposal to limit research to points of which we can now see the bearings in regard to health, etc., I look at as puerile. I thought at first it would be good to limit vivisection to public laboratories; but I have heard only of those in London and Cambridge, and I think Oxford; but probably there may be a few others. Therefore only men living in a few great towns would carry on investigation, and this I should consider a great evil. If private men were permitted to work in their own houses, and required a licence, I do not see who is to determine whether any particular man should receive one. It is young unknown men who are the most likely to do good work. I would gladly punish severely any one who operated on an animal not rendered insensible, if the experiment made this possible; but here again I do not see that a magistrate or jury could possibly determine such a point. Therefore I conclude, if (as is likely) some experiments have been tried too often, or anaesthetics have not been used when they could have been, the cure must be in the improvement of humanitarian feelings. Under this point of view I have rejoiced at the present agitation. If stringent laws are passed, and this is likely, seeing how unscientific the House of Commons is, and that the gentlemen of England are humane, as long as their sports are not considered, which entailed a hundred or thousand-fold more suffering than the experiments of physiologists--if such laws are passed, the result will assuredly be that physiology, which has been until within the last few years at a standstill in England, will languish or quite cease. It will then be carried on solely on the Continent; and there will be so many the fewer workers on this grand subject, and this I should greatly regret. By the way, F. Balfour, who has worked for two or three years in the laboratory at Cambridge, declares to George that he has never seen an experiment, except with animals rendered insensible. No doubt the names of Doctors will have great weight with the House of Commons; but very many practitioners neither know nor care anything about the progress of knowledge. I cannot at present see my way to sign any petition, without hearing what