“The mucous membranes were not the only parts affected by the artificial suppression of the insensible perspiration. We also observed the production of serous effusions in the pericardium, and even in the pleuræ. These effusions thus demonstrate that dropsies are found in the same body as mucous discharges. Several dogs died with paraplegia, and could only drag themselves along on their fore paws; some died atrophied, and their lungs contained miliary tubercules, which appeared to me, from their whiteness and softness, to be of recent formation. It was, therefore, now impossible to doubt the influence of the suppression of the insensible perspiration of the skin upon the changes in the blood, the mucous and serous exudations, and finally, upon the development of local lesions. “But the results of these experiments differ in toto according as the plastering is partial or general, or as it suspends the action of the skin incompletely or completely. In the first case, the alteration of the blood is not carried so far as to cause the dissolution of its organic elements; it can coagulate, and present, in some few cases, a buffy coat of little consistency, bearing some resemblance to that which is found in inflammatory blood. As to the tissues affected, they, however, appear to me to present the anatomical characteristics of the consequences of local inflammation. “But when the application of very adhesive substances upon the whole of the body quickly suppresses the cutaneous exhalation, and consequently prevents the action of the air upon the skin, death takes place much more speedily, and appears to be the result of true asphyxia. The breathing of the animals experimented upon, is difficult; they take deep inspirations, in order to inhale a larger quantity of air than usual; their death is violent, and is often accompanied by convulsive movements. On dissection, we find in the veins and the right cavities of the heart, sometimes also in the left, but very rarely in the arteries, a black diffluent blood, forming sometimes into soft and diffluent coagula, and coagulating, very imperfectly, when exposed to atmospherical air. This dissolution of the blood, favours the formation of large ecchymoses and of effusions into the lungs and other organs, the capillary vessels are usually injected;—one can see that the alteration of the blood has been the true cause of the stagnation of the circulation in this order of vessels. * * * * *