During the many years of his sojourn in Genoa, although he drew both profit and pleasure from that city, Perino had grown weary of it, as he remembered Rome in the happy days of Leo. But although, during the lifetime of Cardinal Ippolito de' Medici, he had received letters inviting him into his service, and he had been disposed to enter it, the death of that lord brought it about that he hesitated to repatriate himself. While matters stood thus, with his many friends urging his return, himself desiring it infinitely more than any of them, and several letters being exchanged, one morning, in the end, the fancy took him, and without saying a word he set off from Pisa and made his way to Rome. There, after making himself known to the most reverend Cardinal Farnese, and then to Pope Paul, he stayed many months without doing anything; first, because he was put off from one day to another, and then because he was attacked by some infirmity in one of his arms, on account of which he spent several hundreds of crowns, to say nothing of the discomfort, before he could be cured of it. Wherefore, having no one to maintain him, and being vexed by his cold welcome from the Court, he was tempted many times to go away; but Molza and many other friends exhorted him to have patience, telling him that Rome was no longer what she had been, and that now she expected that a man should be exhausted and weary of her before she would choose and cherish him as her own, and particularly if he were pursuing the path of some fine art.