It is an unexplained circumstance that, notwithstanding a letter to the Hebdomadal Board from Lord Clarendon, then Chancellor of the University, signifying his assent to a dispensation, enabling Locke to accumulate the degrees of Bachelor and Doctor in Medicine, he never took those degrees. The obstacle may have arisen from himself, or, more probably, it may have been due to some sinister influence on the Hebdomadal Board preventing the assent of that body to the required decree. Any way, it is curious that eleven days after the date of Lord Clarendon's letter is dated the dispensation from the Crown (already referred to on page 13), enabling him to retain his studentship, notwithstanding his neglect to enter holy orders. * * * * * During the summer of 1666, we are introduced to one of the turning-points in Locke's life--his first acquaintance with Lord Shaftesbury, or, as he then was, Lord Ashley. Of the chequered career or the enigmatical character of this celebrated nobleman it is no part of my task to speak. It is enough to say that, as an advocate of religious toleration and an opponent alike of sacerdotal claims in the Church and absolutist principles in the State, he appealed to Locke's warmest and deepest sympathies. The acquaintance was made through David Thomas, an Oxford physician, and the occasion of it was Lord Ashley's coming to Oxford to drink the Astrop waters. The duty of providing these waters (Astrop being a village at some distance from Oxford) seems to have been entrusted by Thomas to Locke, but, there having been some miscarriage, Locke waited on Lord Ashley to excuse the delay. "My lord," says Lady Masham, "in his wonted manner, received him very civilly, accepting his excuse with great easiness, and, when Mr. Locke would have taken his leave of him, would needs have him to stay supper with him, being much pleased with his conversation. But if my lord was pleased with the company of Mr. Locke, Mr. Locke was yet more so with that of my Lord Ashley." The result of this short and apparently accidental interview was the beginning of an intimate friendship, which seems never afterwards to have been broken, and which exercised a decisive influence on the rest of Locke's career.