Pasteur hastened to apply this new method of obtaining pure eggs. Notwithstanding that the malady was universally prevalent, he succeeded, after several days of assiduous microscopic observations, in finding some moths free from corpuscles. He carefully preserved their eggs, as well as other eggs which had proceeded from very corpusculous couples, intending to wait for what these eggs would produce the following year; the first would be probably free from corpuscles, while the latter would contain them. He would thus have in future, though on a small scale, samples of originally healthy and of originally unhealthy cultivations, by the comparison of which with the cultivations of the trade--all more or less smitten with the evil--totally new views might be expected to emerge. Who can tell, thought Pasteur, whether the prosperity of the silk cultivation may not depend on the practical application of this production of pure eggs by means of moths free from corpuscles? * * * * * Scarcely had Pasteur made known, first to the Committee of Alais, and then to the Academy of Sciences, the results of his earliest observations and the inductions to which they pointed, when critics without number arose on all sides. It was objected that the labours of several Italian _savants_ had established beyond all doubt that the corpuscles were a normal element of certain worms, and especially of all the moths when old; that other authors had affirmed it to be sufficient to starve certain worms to make these famous corpuscles appear in all their tissues; and that Dr. Gaetano Cantoni had already tried some cultivations with eggs coming from moths without corpuscles, and that he had totally failed. 'Your efforts will be vain,' wrote the celebrated Italian entomologist Cornalia; 'your selected eggs will produce healthy worms, but these worms will become sickly through the influence of the epidemic demon which reigns everywhere.' Anyone but Pasteur would have been staggered, but he was not the man to allow himself to be discouraged by _à priori_ opinions, and by assertions which were more or less guesswork. He was resolved not to abandon his preconceived idea until experiment had pronounced upon it with precision. All scientific research, in order to be undertaken and followed up with success, should have, as point of departure, a preconceived idea, an hypothesis which we must seek to verify by experiment. To judge of the value of the facts which Pasteur had just announced, it was necessary to know if there existed the relation of cause and effect between the corpuscles and the disease. This was the great point to be elucidated. * * * * *