One of the first experiments was as follows. After their first moulting, he took some very sound worms free from corpuscles, and fed them with corpusculous matter, which he prepared in the following simple manner. He pounded up a silkworm in a little water, and passed a paint-brush dipped in this liquid over the whole surface of the leaves. During several days there was not the least appearance of disease in the worms fed on those leaves; they reached their second moulting at the same time as the standard worms which had not been infected. The second moulting was accomplished without any drawback. This was a proof that all the worms, those infected as well as the standard lot, had taken the same amount of nourishment. The parasite was apparently not present. Matters remained in this state for some days longer. Even the third moulting was got through without any marked difference between the two groups of worms. But soon important changes set in. The corpuscles, which had hitherto only showed themselves in the integuments of the intestines, began to appear in the other organs. From the second day following the third moulting--that is to say, the twelfth after the infection--a visible inequality distinguished the infected from the non-infected worms. Those of the standard lot were clearly in much the best health. On examining the infected worms through a magnifying glass, a multitude of little spots were discovered on their heads, and on the rings of their bodies, which had not before shown themselves. These spots appeared on the exterior skin when the interior skin of the intestinal canal contained a considerable number of corpuscles. It was these corpuscles that impeded the digestive functions, and interfered with the assimilation of the food. Hence arose the inequality of size of the worms. After the fourth moulting, the same type of disease was noticed as that which was breaking out everywhere in the silkworm nurseries, especially the symptom of spots on the skin, which had led to the disease being called _pébrine_. The peasants said that the worms were peppered. The majority of the worms were full of corpuscles. Those which spun their cocoons produced chrysalides which were nothing but corpusculous pulp, if such a term be allowed.