Graduating from South Carolina College he removed to Alabama in 1822. At that time Lewis was just twenty years old. Admitted to the bar, he began the practice of law in Montgomery. His ability in the court room was at once recognized, and had he continued, would doubtless have achieved distinction at the bar; but his pronounced fondness for politics led him early into that arena in which he spent the remainder of his life. His career as a public servant began in the Alabama legislature. During the years 1825-26-27, he represented Montgomery County in the general assembly of the state. At that time he weighed about three hundred and eighty pounds. By dint of ability Mr. Lewis took a foremost position among the Alabama legislators. When scarcely eligible by reason of age, he was chosen for Congress from his district, and continued in the lower house of the National Congress from 1829 to 1844, when he was transferred to the Federal Senate. Mr. Lewis belongs to the states' rights school of politicians, and never had a cause a more fervid advocate. In Congress his influence was pronounced, and for years he was the acknowledged leader of the Alabama delegation in the lower branch of that body. He was unalterably opposed to a protective tariff, and never let an opportunity slip to oppose its fallacy and injustice. His principles were embodied in the platform resolutions adopted by the national democratic convention which met in Baltimore in 1840. Ponderous as he was, Mr. Lewis was not impaired in his activity either as a state legislator or as a congressman. His interest in all matters public enabled him to overcome the hindrance encountered in his enormous weight. It was one of his controlling principles never to be absent from an important committee meeting, where he was always pronounced and firm in the expression of his convictions. When in 1844 he resigned from the House of Representatives to take his seat in the Senate, he was chairman of the committee of ways and means, and the ability shown by him in the lower branch led to his appointment to the chairmanship of the committee on finance when he entered the upper chamber. His life was a perpetual struggle against the difficulty encountered by his weight. He could walk but little, and he could enter but few vehicles. His private carriage had to be specially constructed with respect to strength, and its entrance was of unusual width. In his home a special chair or chairs had to be manufactured adapted to his size, and his bedstead was of far more than ordinary strength. He moved from place to place with exceeding difficulty, but in the constant warfare of the spirit against the flesh the former predominated, for impelled by a gigantic will, he declined to hesitate because of his immense weight and size.