Makers of Modern MedicineWalsh, James J. (James Joseph)
History
Makers of Modern Medicine
Walsh, James J. (James Joseph)
Medicine -- Biography
Mitscherlich, one of the greatest chemists of the time, had just
announced that certain salts--the tartrates and paratartrates of soda
and ammonia--"had the same chemical composition, the same crystalline
form, the same angles in the crystalline condition, the same specific
weight, the same double refraction and, consequently, the same
inclination of the optic axes. Notwithstanding all these points of
similarity, if the tartrate is dissolved in water it causes the plane
of polarized light to rotate while the paratartrate exerts no such
action." Pasteur could not believe that all the chemical and physical
qualities of two substances could be identical and their action to
polarized light be so different. Mitscherlich was known, however, as
an extremely careful observer. For several years Pasteur revolved all
the possibilities in Mitscherlich's observations and, finally, came to
the conclusion that there perhaps existed in the paratartrates, as
prepared by Mitscherlich, two different groups of crystals, the
members of one of which turned the plane of polarization to the right,
the other to the left. These two effects neutralized each other and
apparently the paratartrates have no influence on the polarized beam
of light.
Pasteur found that the paratartrates were composed of crystals that
were dissymmetrical--that is, whose image reflected in a mirror cannot
be superposed on the crystal itself. This idea Pasteur makes clear by
reference to the mirrored image of a hand. The image of the right hand
as {298} seen in a mirror is a left hand. It cannot be superposed on
the hand of which it is the reflection any more than the left hand can
be superposed on the right and have corresponding parts occupy
corresponding places. Pasteur found that the paratartrates were not
only dissymmetrical, but that they possessed two forms of dissymmetry.
The mirrored image of some of the crystals could be superposed on
certain of the other crystals just as the mirror image of the right
hand can be superposed on the actual left hand. He concluded that if
he separated these two groups from each other he would have two very
different substances, and so the mystery propounded by Mitscherlich
would be solved.
Public-domain text, read in full here on John Shaqi.
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