This edition of the _Manual_ appears in three volumes; the first being devoted to General Surgery, the other two to Regional Surgery. This arrangement has enabled us to deal in a more consecutive manner than hitherto with the surgery of the Extremities, including Fractures and Dislocations. We have once more to express our thanks to colleagues in the Edinburgh School and to other friends for aiding us in providing new illustrations, and for other valuable help, as well as to our publishers for their generosity in the matter of illustrations. EDINBURGH, _March_ 1921. CONTENTS PAGE CHAPTER I REPAIR 1 CHAPTER II CONDITIONS WHICH INTERFERE WITH REPAIR 17 CHAPTER III INFLAMMATION 31 CHAPTER IV SUPPURATION 45 CHAPTER V ULCERATION AND ULCERS 68 CHAPTER VI GANGRENE 86 CHAPTER VII BACTERIAL AND OTHER WOUND INFECTIONS 107 CHAPTER VIII TUBERCULOSIS 133 CHAPTER IX SYPHILIS 146 CHAPTER X TUMOURS 181 CHAPTER XI INJURIES 218 CHAPTER XII METHODS OF WOUND TREATMENT 241 CHAPTER XIII CONSTITUTIONAL EFFECTS OF INJURIES 249 CHAPTER XIV THE BLOOD VESSELS 258 CHAPTER XV THE LYMPH VESSELS AND GLANDS 321 CHAPTER XVI THE NERVES 342 CHAPTER XVII SKIN AND SUBCUTANEOUS TISSUES 376 CHAPTER XVIII THE MUSCLES, TENDONS, AND TENDON SHEATHS 405 CHAPTER XIX THE BURSÆ 426 CHAPTER XX DISEASES OF BONE 434 CHAPTER XXI DISEASES OF JOINTS 501 INDEX 547 LIST OF ILLUSTRATIONS FIG. PAGE 1. Ulcer of Back of Hand grafted from Abdominal Wall 15 2. Staphylococcus aureus in Pus from case of Osteomyelitis 25 3. Streptococci in Pus from case of Diffuse Cellulitis 26 4. Bacillus coli communis in Pus from Abdominal Abscess 27