237, _Dr. Addington_ stated, that the extremity of the rectum was extremely painful, and surrounded by excoriations and ulcers. _Mr. Brodie_ has stated, in the paper to which we have so often alluded, that the organic lesions occasioned by arsenic are confined to the stomach and intestines, and that he _never found any appearance of inflammation in the pharynx or œsophagus_. This statement, however, is at variance with a great weight of authority; we have ourselves witnessed cases in which dissection has demonstrated extensive inflammation in these parts; indeed it would appear, that this poison acts more particularly on the mucous membranes; and it is reasonable therefore to conclude, that those with which it comes in actual contact will not escape its virulence. The serous membranes which receive less blood, and more lymphatics, are necessarily less affected by it. In the case of _William Mitchell_, as related at _page_ 188, the patient complained of soreness of the eyes, heat and uneasiness in the mouth and throat; and the surgeon observed the membrane on the palate and uvula to be detached; so in that, again, of _Mr. Blandy_, _Dr. Addington_ found on inspection that “his tongue was swelled, and his throat inflamed and excoriated; his lips, especially the upper one, dry and rough, and having angry pimples on them; the inside of his nostrils in the same condition, and his eyes a little blood shot.” (_Append._ _l. c._). In the celebrated Scotch case of _Oglivy_ and _Nairne_ (_see page_ 184) _Peter Meik_, surgeon of Alyth, deposed, that, upon inspecting the body four or five days afterwards, he found “the tongue swelled beyond its natural size, and cleaving to the roof of the mouth, which he had never observed after a natural death.” Many more instances might be adduced to shew that the fauces, pharynx, and œsophagus are very frequently inflamed and excoriated by the ingestion of arsenic. Mortification of the pudenda[237] has been said to be an effect peculiar to the action of arsenic; certain it is that in males, priapism is sometimes a symptom of this poison, and the penis is found swollen and red after death, as was observed in the case of _William Mitchell_ (p. 190). The scrotum was also enlarged and of a dark colour. We have been long aware that persons exposed to the fumes of arsenic, or accustomed to handle any of its preparations, have been liable to a peculiar affection of these parts, but we have generally explained the fact by supposing that the poison had in such cases, been locally applied to them. The author has been lately informed by his friend _Mr. Parkes_, that several persons in his establishment were thus attacked, during the time they were engaged in preparing an arsenical solution, as a dye for the calico printers; and we have stated on another occasion,[238] that the smelters and workmen engaged in the copper works, and tin burning houses of Cornwall, are