the end of which it returned, and harrassed her for about twelve months.[272] The author, in his _Pharmacologia_,[273] has cited a case from _Hufeland’s Journal_, (vol. ix) wherein mercurial influence, after its complete subsidence, had been renewed by doses of opium. In the trial of _Miss Butterfield_, at the Croydon assizes, for poisoning _Mr. Scawen_, in the year 1775, the merit of the case entirely hinged upon this question. See vol. 1, p. 303. _Physiological action of Corrosive Sublimate._ When this salt is introduced into the stomach in a large dose, it immediately exerts a corrosive action on that organ, in consequence of which the heart and brain become sympathetically affected, and death results from the suspension of their functions. For this view of the _modus operandi_ of this mercurial salt we are indebted to _Mr. Brodie_,[274] whence it would appear that its physiological action is very different from that of arsenious acid; the former acting as a simple _escharotic_, on the coats of the alimentary canal, the latter requiring to be absorbed, before it can display its energies. These observations, however, apply only to those cases in which the quantity of poison has been so considerable as to destroy life in a few hours; where the dose has been small, and the symptoms have arisen from its frequent repetition, the salt produces its effects by a different mode of operation. In this latter case it is absorbed, and carried into the current of the blood, so as to be distributed to every part of the living system; and it has been asserted that, after the long continued and improper use of mercury, it has been discovered in different parts of the body, and even in the brain, in the form of globules. In this way then deleterious effects may arise from the external application of corrosive sublimate, and numerous instances are recorded where such consequences have followed the injudicious use of lotions and plasters, into which it had entered as an ingredient.[275] In the _Medical Repository_, for December, 1821, _Mr. Sutleffe_ has communicated the case of a girl of five years of age, who became salivated, and died, in consequence of an application made to the head for _tinea capitis_, consisting of pomatum rubbed up with a few grains of _corrosive sublimate_. _Antidotes to Corrosive Sublimate._