The diplomatic relations of the Holy See at Madrid were at this juncture in the hands of Count Castiglione, with whom we have formerly become acquainted in the service of Dukes Guidobaldo and Francesco Maria, and whom we last noticed as agent for the Marquis of Mantua at the Roman court in 1522, where he was again sent in the same capacity on the election of Clement VII. The position of the new Pontiff soon became one of great delicacy, and already were those difficulties closing around him, which, during his reign, completed the first great breach in the Romish church, and consummated the mischiefs of foreign invasion in the Peninsula. The struggle for universal dominion of those youthful rivals who occupied the thrones of France and the Empire, was convulsing civilised Europe, and Italy was obviously fated to become the permanent prey of the victor. In these circumstances, a character so deficient in energy and decision was singularly inadequate to cope with the necessities of the times; and Clement's influence at Florence, far from affording a prop to the tottering papacy, tended yet more to distract his irresolute purpose. Falling back upon the usual expedient of small minds, he adopted a neutral attitude between the two contending potentates: but the days were past when Pontiffs could grasp the balance of power, or curb a dangerous ascendancy; and Clement's views aimed not beyond siding with a momentary victor. To carry out such policy fine diplomacy was requisite, and Castiglione was selected to watch the interests of Rome at the Spanish court. In the autumn of 1524, he accepted this Nunziatura, to which was joined the lucrative collectorship of Spain; and after visiting the shrine of Loreto, he reached Madrid in the following March.