Giovanni Maria, second son of Giulio Cesare Count of Camerino, was sent to Venice on Borgia's approach, and so avoided the fate of his family. On the death of Alexander VI., being then in his twenty-second year, he made a descent upon La Marca, and possessed himself of his father's seigneury, in defiance of his infant nephew's title to it. His authority was recognised by the Holy See, at a time when the hereditary principle was loose, and a strong hand constituted the best claim. He found a warm supporter in Leo X., through sympathy of their common hatred for the della Rovere race, and received from him the lordship of Sinigaglia and prefecture of Rome, on the deprivation of Francesco Maria, along with the additional dignity of Duke of Camerino. After the death of Leo, Sigismondo for a few months made good his authority at Camerino, until supplanted by the usurper, whose title was conveniently completed by his nephew's murder; whereupon he became _de jure_ its sovereign, and continued in undisturbed possession of his ill-gotten honours. On the death of Duke Giovanni Maria, in August 1527, the male heir of the fief was Ercole Varana, whose eldest son, Matteo, had been destined by the Duke's will to become husband of his infant daughter Giulia, then but four years old. This arrangement was, however, resolutely opposed by his widow, Caterina Cibò,[*32] niece of Leo X.; and ere any steps could be taken to carry it into effect, the town was sacked by Sciarra Colonna, who, with his son-in-law, Rodolfo Varana, a bastard of its last lord, drove Caterina and her child into the citadel. Forgetting the double feud of Francesco Maria with her husband and her Medicean relations, she in her extremity besought his aid, offering to plight her daughter's hand to his son, Prince Guidobaldo. The proposal found him ingloriously inactive in Umbria, during the negotiations for release of Clement from S. Angelo, and, readily accepting it, he sent troops to relieve the suppliant lady, who continued for several years to administer the state in name of Giulia, with the passive countenance of her cousin the Pontiff. But the jealousy which rankled in the breast of his Holiness against the della Rovere princes, fretted at an arrangement so conducive to their aggrandisement, and at the first congress of Bologna he sought to break it off. The Duke's answer, as reported by Leonardi, was, that he would risk life and state rather than withdraw from the engagement, and that, if driven to defensive measures, the Pope should in the end bear the expenses of the war. With the recent and costly failure of Leo against Urbino in their recollection, the consistory would lend no sanction to the inclinations of their head, and so the matter rested until the return of Clement from France. Francesco Maria then formally applied for the papal sanction to a union of his son with the heiress of Camerino, but was put off on account of her tender age.