The _symptoms_ generally come on rapidly, the individual appearing confused, and unable to walk steadily. This degree of intoxication soon passes into the stage of complete stupor and coma, and unless there is vomiting collapse soon sets in. In some cases a remission of the symptoms has occurred, death being postponed for a day or longer. As the alcohol is eliminated by the lungs, stupor from drink may be detected by the odor of the breath. The countenance is usually flushed, and the pupils are dilated, but in cases of acute poisoning the patient may be deadly pale. The pupils are not contracted, as in poisoning by opium; moreover, the individual may generally be roused for a few moments by a loud noise, &c.; a circumstance which may prevent intoxication being mistaken for concussion of the brain. Diluted spirits produce a state of excitement, terminating in stupor. It must be remembered that alcoholic liquids have been frequently made the vehicles of more virulent poisons. As regards _treatment_, it is only necessary to say that the poison is to be removed as quickly as possible by the stomach-pump. Cold affusion should be employed, and the diluted liquor ammoniæ, or carbonate of ammonia, administered. Subsequently warmth must be promoted. NITRO-BENZOLE AND ANILINE.—A compound, made from the rectified products of coal tar and nitric acid, and known as _nitro-benzole_, is sometimes used as a substitute for essential oil of almonds. It is sold to perfumers under the name of “essence of mirbane.” A lad employed in some chemical works in the early part of 1862, finding a syphon did not act, sucked through it some of the fluid, which happened to be nitro-benzole. No immediate effect resulted, but in a few hours he felt as if he were drunk. Stupor came on, and ended in death twelve hours after swallowing the poison. Another product of the destructive distillation of coal in gas-making is _aniline_ (into which nitro-benzole is converted in the human body) a colorless, limpid, acrid, and poisonous liquid. It has given rise to very alarming symptoms when swallowed, as well as when inhaled in vapor. It produces a remarkable blue or purple discoloration of the body, particularly the lips and nails. COCCULUS INDICUS.—The kernel of the berry of the Menispermum cocculus, or Levant nut, imported from the East Indies, contains from one to two per cent. of a poisonous principle named _picrotoxine_. Thieves sometimes mix a decoction or extract of the berries with spirits or beer, to give these drinks an intoxicating property (hocussing). Dishonest publicans, too, first reduce their beer by means of salt and water, and afterwards give it intoxicating properties by adding cocculus extract. The same substance is used by poachers to destroy fish. The symptoms produced appear to be a peculiar stupor, a complete loss of voluntary power, with a consciousness of passing events.