It is assumed that all who are recorded as having offspring were married to normals. Examination of the pedigree brings out the facts (1) that all affected individuals have an affected parent; (2) that none of the unaffected individuals, though sprung from the affected, ever have descendants who are affected, and (3) that in families where both affected and unaffected {173} occur, the numbers of the two classes are, on the average, equal. (The sum of such families in the complete pedigree is thirty-nine affected and thirty-six normals.) It is obvious that these are the conditions which are fulfilled in a simple Mendelian case, and there is nothing in this pedigree to contradict the assertion that brachydactyly, whatever it may be due to, behaves as a simple dominant to the normal form, _i.e._ that it depends upon a factor which the normal does not contain. The recessive normals cannot transmit the affected condition whatever their ancestry. Once free they are always free, and can marry other normals with full confidence that none of their children will show the deformity. [Illustration: FIG. 34. Pedigree of Drinkwater's brachydactylous family. The affected members are indicated by black and the normals by light circles.] {174} The evidence available from pedigrees has revealed the simplest form of Mendelian inheritance in several human defects and diseases, among which may be mentioned presenile cataract of the eyes, an abnormal form of skin thickening in the palms of the hands and soles of the feet, known as tylosis, and epidermolysis bullosa, a disease in which the skin rises up into numerous bursting blisters. Among the most interesting of all human pedigrees is one recently built up by Mr. Nettleship from the records of a night-blind family living near Monpelier in the south of France. In night-blind people the retina is insensitive to light which falls below a certain intensity, and such people are consequently blind in failing daylight or in moonlight. As the Monpelier case had excited interest for some time, the records are unusually complete. They commence with a certain Jean Nougaret, who was born in 1637, and suffered from night-blindness, and they end for the present with children who are to-day but a few years of age. Particulars are known of over 2000 of the descendants of Jean Nougaret. Through ten generations and nearly three centuries the affection has behaved as a Mendelian dominant, and there is no sign that long-continued marriage with folk of normal vision has produced any amelioration of the night-blind state. {175} [Illustration: FIG. 35. Pedigree of a haemophilic family. Affected (all males) represented by black, and normals of both sexes by light circles. (From Stahel.)]