Infantilism has been ascribed to syphilis, tuberculosis, alcoholism, etc., of the parents. Brissaud in 1907 advanced the theory that it was a hypothyroid symptom. His views have been supported by various other writers, although not shared by either Falta or Kraepelin. The latter has also described mental conditions more or less suggesting feeblemindedness and associated with lesions of the hypophysis, the pineal gland, the adrenals, the sexual glands and the thymus. Lesions in the anterior lobe of the pituitary result in gigantism or acromegaly, with a childish mentality most marked in the emotional sphere. These persons are usually indifferent, good-natured and boastful, and at the same time clumsy and inactive. A diminished activity of the glandular portion of the hypophysis means dwarfism. Lesions of the posterior or "nervous" lobe may cause "dystrophia adiposo genitalis," the "adipositas dolorosa" of Dercum. The mental status in this condition Kraepelin compares to that described in acromegaly—apathy and indifference, with occasional restless or excited types. The intellectual capacity may be normal, mediocre or somewhat deficient. The pineal gland is spoken of as having a very definite relation to sexual development. Extirpation is said to lead to rapid development of the body, the accumulation of fat and early sexual development,—a condition described by Pellizzi as "makro-genitosomia praecoce." Schüller in fifty-one cases with pineal involvements found ten occurring during the first decade of life. Death usually takes place within a few months or years. Similar conditions result from hyperactivity of the adrenal cortex,—rapid development of the body, and particularly of the sexual organs, obesity and overgrowth of the hair and beard. Wiesel described as a "suprarenal genital symptom complex" cases of pseudo-hermaphrodism in women.