Timme[122] has described a psychic makeup due to subinvolution of the thymus. "The mental picture presented by these subinvoluted thymic states is also of great importance, for analogous to their structural lack of differentiation is their psychic makeup. They remain child-like in their character, so that they are self-centered; simple in their mental processes and imitative; looking for protection and care, and more or less unfitted for the active struggles of life. They are obstinate and negativistic; if, however, an efficient compensation takes place, then, although the mental development may have been delayed, it nevertheless seems finally to reach complete maturity; and these individuals are among the brightest and most intelligent of their community." In cases of precocious involution of the thymus he finds the mental condition to be of chief interest. "They are precocious, with much initiative, are easily aroused to anger and are resentful. They have cruel instincts and show little inhibition. Although they seem far advanced for their years while still young, yet they never seem thoroughly to mature, and become blocked in early adolescence. They seem to retain their impulsive, unreasoning characteristics, brook no restraint and remain constantly a prey to their easily aroused anger." Of thyroid insufficiency he says: "Mentally, the patient is dull, sluggish and with little initiative. He moves slowly and thinks slowly, is extremely forgetful and his lethargy is occasionally disturbed by outbursts of anger due probably to his maladjustment to the more quickly moving world about him." In his summary of the hyperthyroid makeup, Timme says: "Both mind and body are everlastingly busy. And not only with present problems, but anticipatory of tomorrow's as well. The patient shows no rest or relaxation. His mind, filled with echoes of the day's troubles, prevents his falling to sleep until long after he retires, and he is again awake and immediately on the "qui vive" as soon as daylight comes." Statistics on endocrine conditions are unfortunately not available as yet. CHAPTER XIII THE MODERN PROGRESS OF PSYCHIATRY