extremities when the swelling and stiffness of the muscles are at their height. Profuse sweats, tingling and itching of the skin and in some instances hives (Urticaria) have been described. There are emaciation and anemia. In the severe cases the appearance may be like that in the third week of typhoid fever. In mild cases the fever and muscular symptoms subside in ten to fourteen days, in others only after two or three months. The mortality, from one to thirty per cent, seems to depend upon the virulence and number of parasites. PHYSICIANS' TREATMENT.--If discovered within twenty-four to thirty-six hours, thoroughly empty the bowel with purgatives. Rhubarb and senna, or an occasional dose of calomel may be given. Relieve the pains afterwards and support the strength. [SKIN DISEASES 53] DISEASES OF THE SKIN. The skin is divided into three layers. Beginning with the outer one and naming inward, they are named as follows: The outer layer is called the epidermis or cuticle (near or upon the skin). The second layer is called the corium, derma cutis vera, or true skin. The third layer is called the sub-cutaneous (under the skin) (fatty or connective) tissue. This last layer contains the sweat glands, the lower end of the deep-seated hair follicles, (little sacs containing the roots of the hair) and larger branches of the lymphatics, blood vessels and nerves, and serves in general as a bed for the true skin to rest upon, and by which the true skin is connected with the deeper parts, muscles, etc. The appendages of the skin are the hair, nails, sebaceous and sweat-glands. The discharge from the sweat-glands form a little or larger tumor. The contents of a wen are from sebaceous glands--fat secretions--fat tumor. The following names are frequently mentioned in the skin diseases: Macule. (Spots, patches). Skin is altered in color, but the skin is not raised or depressed; freckle, etc. Papule. (Pimple). Elevated piece of skin, varying in size from a pin-head to a coffee bean. Tubercle. (Node-lump). A solid elevation of the skin, varying in size from a pea to a cherry. Tumors. These are soft or firm elevations of the skin, like a wen or hard lump. They are always deep-seated. Wheel. A round flat, white or pink elevation of the skin; such as hives, mosquito bites, etc. Vesicle. This is a pin-head or pea-sized elevation of the outer layer (epidermis) filled with a watery fluid. Bleb. (Bulla). A circumscribed elevation of the skin and contains a watery fluid, such as a burn, etc. Pustule. A rounded elevation of the outer layer (epidermis) of varying size, containing pus (matter). A vesicle, bleb, and pustule are hollow; macule, papule, and tubercle are solid. Scale. (Squama). This is a dry attached or unattached thin piece from the skin as a result of disease of the skin. Crust. This is a dried mass as a result of fluid oozing from a diseased skin. Excoriation. Like a scratch mark.