Of the neuralgias of youth, the majority either disappear altogether after a first attack, or recur a certain number of times during some years, the neuralgic tendency either disappearing or becoming greatly mitigated when the process of bodily consolidation is over. In another group the neuralgic tendency is never lost, but the form of the attacks changes, and there is far less spontaneity in the manner of their production. It is exceedingly common to see delicate boys and girls between puberty and the age of eighteen or twenty, attacked with typical migraine, which recurs regularly every three or four weeks for perhaps two or three years, then ceases to occur at regular periods, then loses the tendency to stomach complication; and, by the age of twenty-five or somewhat later, has left, as its only relic, a tendency to attacks of ophthalmic neuralgia, which come on when the patient is excessively fatigued, or encounters the close air of a theatre, or undergoes an unusual strain of mental excitement or anxiety, etc.; but which never come on without some such special provocation. So, again, there is a variety of sciatica which belongs mainly to the period between puberty and the twenty-fifth to thirtieth year, and which seems really to belong, pathologically, to the age of unsettled and irregular sexual function, the tendency to it usually disappearing after the patient has settled down happily in married life. Ovarian and mammary neuralgia have very commonly a similar history. On the other extreme we find the neuralgias of the period of bodily decay: these are of very bad prognosis. A neuralgia which first develops itself after the arteries and capillaries have begun to change decidedly in the direction of atheroma is extremely likely, even if apparently cured for a time, to recur again and again, with ever-increasing severity, and to haunt the patient for the remainder of his days. It therefore becomes exceedingly important, in a prognostic point of view, to assure ourselves as soon as possible whether this arterial degeneration has decidedly commenced; and for this purpose I am in the habit of insisting to pupils on the great importance of sphygmographic examination for all neuralgic patients who have passed the middle age. Where we get the evidence which is furnished by the formation of a distinctly square-headed radial pulse-curve, even though there be no palpable cord-like rigidity of superficial arteries, we are bound to be exceedingly cautious of giving a favorable prognosis.