(_e_) We come now to a group of complications of neuralgia which are exceedingly important, and by no means adequately appreciated as yet, viz., the acute inflammations which directly result from neuralgic affections in a certain percentage of cases, probably much larger than has been at all generally suspected. The most familiar of the inflammatory complications of neuralgia is herpes zoster, the favorite seat of which is the skin which covers one or more of the intercostal spaces: the eruption, as occurring in this situation, is so well known that it would be waste of time to describe it. In young subjects zoster is commonly painless, at least the sensations are those of heat, pricking, and irritation, rather than of acute pain; but from puberty onward there is an increasing tendency, especially in those otherwise predisposed to neuralgia, for zoster to be preceded, accompanied, or followed by neuralgia of the intercostal nerves corresponding to the distribution of the eruption. Most commonly, the eruptive period is, in my experience, nearly or quite free from neuralgia, but it often recurs, or breaks out for the first time, when the vesicles are drying up, but more especially if, as is sometimes the case, especially in elderly people, the scabs fall off and leave superficial ulcers. Neuralgia may last, after herpes zoster, for any time from a few days to many weeks, and I have known it so agonizingly severe and so persistent as actually to kill an aged woman from sheer exhaustion. In spite of sundry objections that have been raised to the theory of the nervous origin of zoster, it appears to me that the evidence in favor of it is overwhelming, more especially now that it is proved that the disease, with all the same characteristics presented by it when seen on the chest or abdomen, may occur on the face (following the branches of the trigeminus), or on the forearm (following the course of nerves from the brachial plexus). Two of the severest cases of neuralgia attending herpes that I have ever seen were in private patients (whose family history, unfortunately, I had no means of ascertaining) who were affected, respectively, in the facial and in the brachial nerve-territories.